Exploring the Innovative Field of Spatial OMICS Platforms

The number of spatial omics platforms has increased along with the application of spatial omics. The greatest platforms now on the enterprises will be examined, with an emphasis on the most recent developments. Readers will learn how to choose the best technology for their research needs.

The capability of spatial OMICS as a tool for cancer diagnostics and the expanding application of this technology in medication development. Understanding the unique cell interactions at the tumor border is conceivable, which is crucial for cancer detection. Thus, it is anticipated to fuel the market growth. In addition, according to a research report by Astute Analytica, the Global Spatial OMICS Market is likely to grow at a compound annual growth rate (CAGR) of 10.3% over the projection period from 2023 to 2031.

The Innovative Platforms of Spatial OMICS

CosMx SMI and NanoString’s GeoMx DSP

The GeoMx DSP from NanoString is a high-quantity in situ spatial analyzer that enables completely automated multi-cellular transcriptome profiling. Leading scientists from all around the world have already purchased more than 475 of the company's spatial biology instruments as of September 30, 2022.

Vizgen’s MERSCOPE Platform

MERSCOPETM (powered by MERFISH [multiplexed error-robust fluorescence in situ hybridization] technology). It enables users to immediately identify and measure the location in space of hundreds of RNA species. Furthermore, in situ within individual cells without the requirement for downstream sequencing. It is the first in situ platform with high multiplexing, high resolution, and real single-cell spatial genomics support. Through a user-friendly web-based portal, the platform enables users to create unique gene panels that directly answer their research objectives.

Xenium and 10x Genomics’ Visium Platforms

Visium, a platform for objective spatial discovery from 10x Genomics, was introduced. The entire transcriptome may be mapped in FFPE or fresh frozen tissues with morphological context thanks to Visium. Over 365 articles and preprints have so far referenced the technique. The new Xenium technology for in situ analysis allows for specific spatial profiling of proteins and genes at subcellular resolution. It was just made commercially available. The platform comes with a flexible and user-friendly tool in addition to a wide selection of carefully selected, adaptable, and premium panels.

Molecular cartography

The Molecular Cartography approach is popular with clients because it offers a clear, high-sensitivity, high-resolution, 3D perspective of subcellular spatial biology. Molecular cartography reveals the intricate transcriptional landscape of the cell without affecting the tissue section or cell culture sample. Resolve Biosciences has managed thousands of customer projects over the past year. In the future, Protein, DNA, and metabolic data layers are projected to be able to be analyzed using molecular cartography.

Conclusions

It might be challenging to stay up to date with the most recent developments in the field of spatial omics due to its extraordinary rate of advancement. Fortunately, the majority of the systems covered above can now detect both RNA and proteins while prices are continually decreasing. People's platform choice may also be influenced by plex, resolution, whole-slide capabilities, suitability for various sample types, throughput, accuracy, sensitivity, and repeatability.